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Publications

Case Study
Novogene Single-cell and Spatial Multi-omics Case Study Ⅱ
  • 2024
  • 10X Genomics single cell sequencing
  • Human
  • Case Study
Novogene 10x Single Cell RNA Sequencing: Project Experience Showcase
  • 2024
  • 10X Genomics single cell RNA sequencing
  • Animal
  • Case Study
Novogene's Single-Cell Sequencing Services Facilitate Mammalian Stem Cell Regeneration Research
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • Customer Interview
Application of Whole Transcriptome Sequencing in Cancer Research
  • 2023
  • Whole Transcriptome Sequencing
  • Human
  • Case Study
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
  • 2023
  • Whole Genome Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • CELL
  • IF 66.85
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
  • 2023
  • De novo Sequencing, Whole Genome Sequencing, Hi-C
  • Plant
  • NATURE GENETICS
  • IF 41.307
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Human
  • Molecular Cancer
  • IF 41.444
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Animal
  • CELL
  • IF 66.85
An unusual tandem kinase fusion protein confers leaf rust resistance in wheat
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Plant
  • NATURE GENETICS
  • IF 41.307
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
  • 2023
  • Whole Genome Sequencing
  • Human
  • NATURE
  • IF 64.8
A graph-based genome and pan-genome variation of the model plant Setaria
  • 2023
  • Whole Genome Sequencing
  • Plant
  • NATURE GENETICS
  • IF 30.8
Historical DNA reveals climate adaptation in an endangered songbird
  • 2023
  • Whole Genome Sequencing
  • Animal
  • Nature Climate Change
  • IF 30.7
Precise integration of large DNA sequences in plant genomes using PrimeRoot editors
  • 2023
  • Whole Genome Sequencing
  • Plant
  • NATURE BIOTECHNOLOGY
  • IF 68.164
Improved cytosine base editors generated from TadA variants
  • 2023
  • Whole Genome Sequencing
  • Human
  • NATURE BIOTECHNOLOGY
  • IF 46.9
Resurrection of endogenous retroviruses during aging reinforces senescence
  • 2023
  • RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Microbial
  • CELL
  • IF 66.85
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
  • 2023
  • RNA Sequencing, Whole Exome Sequencing
  • Human
  • NATURE
  • IF 64.8
Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders.
  • 2023
  • RNA Sequencing
  • Microbial
  • Cell Host & Microbe
  • IF 31.316
Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
  • 2023
  • Metatranscriptome Sequencing
  • Animal
  • Nature Microbiology
  • IF 30.964
Differential Responses of the Gut Microbiome and Resistome to Antibiotic Exposures in Infants and Adults
  • 2023
  • 16S/18S/ITS Amplicon Metagenomic Sequencing, Metagenomics
  • Microbial
  • Cell Host & Microbe
  • IF 31.316
Hyperactive nanobacteria with host-dependent traits pervade Omnitrophota
  • 2023
  • Metagenomics
  • Microbial
  • Nature Microbiology
  • IF 30.964
Linking chromatin acylation mark-defined proteome and genome in living cells
  • 2023
  • ATAC-seq, ChIP-seq, RNA Sequencing, Hi-C
  • Human
  • CELL
  • IF 66.85
Nano-DMS-MaP allows isoform-specific RNA structure determination
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Human
  • NATURE METHODS
  • IF 47.99
ThPOK is a critical multifaceted regulator of myeloid lineage development
  • 2023
  • RNA Sequencing
  • Human
  • NATURE IMMUNOLOGY
  • IF 30.5
Mitotic clustering of pulverized chromosomes from micronuclei
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
  • 2023
  • RNA Sequencing
  • Plant
  • NATURE GENETICS
  • IF 41.307
3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
  • 2023
  • RNA Sequencing
  • Human
  • Molecular Cancer
  • IF 41.444
Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Microfluidic templated stem cell spheroids microneedles for diabetic wound treatment
  • 2023
  • RNA Sequencing
  • Human
  • ADVANCED MATERIALS
  • IF 32.086
Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Precise transcript targeting by CRISPR-Csm complexes
  • 2023
  • RNA Sequencing
  • Microbial
  • NATURE BIOTECHNOLOGY
  • IF 68.164
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
  • 2023
  • RNA Sequencing, CUT&Tag
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 39.3
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation
  • 2023
  • CRISPR Screening (off-target)
  • Animal
  • CELL RESEARCH
  • IF 46.297
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs
  • 2023
  • ChIP-seq, RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • CELL
  • IF 64.5
Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells
  • 2023
  • ChIP-seq, RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • Cell Discovery
  • IF 38.079
Rewiring cancer drivers to activate apoptosis
  • 2023
  • ChIP-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 64.8
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer
  • 2023
  • ATAC-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • SCIENCE
  • IF 63.714
Lysine catabolism reprograms tumour immunity through histone crotonylation
  • 2023
  • 10X Genomics single cell sequencing, ChIP-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
A differentiation roadmap of murine placentation at single-cell resolution
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • Cell Discovery
  • IF 38.079
NK-like CD8+ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • Science Immunology
  • IF 30.63
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
  • 2023
  • 10X Genomics single cell sequencing
  • Microbial
  • NATURE MATERIALS
  • IF 47.656
Single-cell transcriptomic analysis of endometriosis
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • NATURE GENETICS
  • IF 41.307
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
  • 2023
  • 16S/18S/ITS Amplicon Metagenomic Sequencing, RNA Sequencing
  • Microbial
  • Case Study
Novogene Single-cell and Spatial Multi-omics Case Study
  • 2023
  • Single Cell RNA Sequencing
  • Human
  • Case Study
Bat Immunity: Unlocking the Lineage-Specific Molecular Adaptations with Genetic Bases
  • 2023
  • De novo Sequencing, Whole Exome Sequencing, Hi-C
  • Animal
  • Case Study
Biosynthesis and recycling of magnetite nanocatalysts from Fe-rich sludge
  • 2022
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • IF 10.2
Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
  • 2022
  • Whole Exome Sequencing, Whole Transcriptome Sequencing
  • Animal
  • IF 14.957
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
  • 2021
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • IF 12.121
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
  • 2021
  • ATAC-seq, ChIP-seq, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • Nucleic Acids Res
  • IF 11.501
Homology-mediated inter-chromosomal interactions in hexaploid wheat lead to specific subgenome territories following polyploidization and introgression
  • 2021
  • RNA Sequencing, Whole Genome Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Plant
  • Genome Biology
  • IF 10.806
The Gut Microbiome and Energy Source of the Giant Panda
  • 2021
  • Metagenomics
  • Human
  • Case Study
Horizontal gene transfer of Fhb7 for Fusarium head blight resistance in wheat
  • 2020
  • De novo Sequencing, RNA Sequencing
  • Plant
  • Science
  • Case Study
A Genomic and Epigenomic Atlas of Prostate Cancer in Asian Populations
  • 2020
  • RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • Nature Genetics
Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy
  • 2020
  • Whole Genome Sequencing
  • Microbial
  • Advanced science
  • IF 15.84
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavio
  • 2019
  • 10X Genomics single cell sequencing
  • Animal
  • Cell
  • 31.398
B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
  • 2019
  • 10X Genomics single cell sequencing
  • Animal
  • Nature Communications
  • 11.878
Pathogen-targeting glycovesicles as a therapy for salmonellosis
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Communications
  • 11.878
Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Advanced Science
  • 15.804
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Cell Host & Microbe
  • 17.87
A circRNA signature predicts postoperative recurrence in stage II/III colon cancer
  • 2019
  • circular RNA Sequencing
  • Human
  • EMBO Mol Med
  • 10.624
Penaeid shrimp genome provides insights into benthic adaptation and frequent molting
  • 2019
  • De novo Sequencing
  • Animal
  • Nature communications
  • 12.353
Marine biofilms constitute a bank of hidden microbial diversity and functional potential
  • 2019
  • Metagenomics
  • Microbial
  • Nature Communications
  • 11.878
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
  • 2019
  • RNA Sequencing
  • Animal
  • Circulation Research
  • 15.862
Spliceosome disassembly factors ILP1 and NTR1 promote miRNA biogenesis in Arabidopsis thaliana
  • 2019
  • small RNA Sequencing
  • Plant
  • Nucleic Acids Research
  • 11.147
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
  • 2019
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • 11.878
Phylogenomics Reveals an Ancient Hybrid Origin of the Persian Walnut
  • 2019
  • Whole Genome Sequencing
  • Plant
  • Molecular Biology and Evolution
  • 14.797
The allotetraploid origin and asymmetrical genome evolution of common carp Cyprinus carpio
  • 2019
  • Whole Genome Sequencing
  • Animal
  • Acta Pharmaceutica Sinica B
  • 12.353
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
  • 2018
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Human
  • Nature Communications
  • 12.124
The Gastrodia elata genome provides insights into plant adaptation to heterotrophy
  • 2018
  • De novo Sequencing
  • Plant
  • Nature Communications
  • 12.353
A genome for gnetophytes and early evolution of seed plants
  • 2018
  • De novo Sequencing
  • Plant
  • Nature Plants
  • 10.3
Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
  • 2018
  • Whole Exome Sequencing
  • Human
  • European Respiratory journal
  • 12.242
Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
  • 2018
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • 12.124
A mapping framework of competition–cooperation QTLs that drive community dynamics
  • 2018
  • Whole Genome Sequencing
  • Microbial
  • NATURE COMMUNICATIONS
  • 12.353
Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis
  • 2018
  • Whole Genome Sequencing
  • Plant
  • Nature Communications
  • 12.124
Continental-scale pollution of estuaries with antibiotic resistance genes
  • 2017
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Microbiology
  • 14.182
The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
  • 2017
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Communications
  • 11.329
Scallop genome provides insights into evolution of bilaterian karyotype and development
  • 2017
  • De novo Sequencing
  • Animal
  • Nature Ecology & Evolution
The Apostasia genome and the evolution of orchids
  • 2017
  • De novo Sequencing
  • Plant
  • Nature
  • 40.137
Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins
  • 2017
  • De novo Sequencing
  • Animal
  • Nature Communications
  • 12.124
The Aegilops tauschiigenome reveals multipleimpacts of transposons
  • 2017
  • De novo Sequencing
  • Plant
  • Nature Plants
  • 10.3
Lineage-specific functions of TET1 in the postimplantation mouse embryo
  • 2017
  • Oxidative Bisulfite Sequencing (oxBS)
  • Animal
  • Nature Genetics
  • 27.959
Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma
  • 2017
  • Whole Genome Sequencing
  • Human
  • Gastroenterology
  • 18.392
Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes
  • 2016
  • RNA Sequencing
  • Microbial
  • Genome Research
  • 14.63
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome
  • 2016
  • Whole Exome Sequencing
  • Human
  • American Journal of Human Genetics
  • 10.794
Population genomics reveals low genetic diversity and adaptation to hypoxia in snub-nosed monkeys
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
History and temperate adaptation of the honey bee subspecies Apis mellifera sinisxinyuan n. ssp.
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
  • 2014
  • Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • Genome Biology
  • 10.81
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
  • 2013
  • RNA Sequencing
  • Human
  • Nature Structural & Molecular Biology
  • 11.633
The genetic basis of whilte tigers
  • 2013
  • Whole Genome Sequencing
  • Animal
  • Current Biology
  • 10.445