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Publications

Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
  • 2023
  • Whole Genome Sequencing
  • Plant
Bat Immunity: Unlocking the Lineage-Specific Molecular Adaptations with Genetic Bases
  • 2023
  • De novo Sequencing, Whole Exome Sequencing, Hi-C
  • Animal
Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis summary
  • 2023
  • Target Region Sequencing
  • Human
A survey of the sorghum transcriptome using single-molecule long reads
  • 2023
  • Isoform Sequencing
  • Plant
Case Study
The Application of Multiomics in the Gut-brain Axis of Honeybee Model
  • 2023
  • Animal
  • Case Study
Novogene's Single-Cell Sequencing Services Facilitate Mammalian Stem Cell Regeneration Research
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • Customer Interview
Advancing Polyploid Assembly and Large-Genome Assembly in Plants Through Long-Read Sequencing
  • 2023
  • Plant
  • Case Study
The Application of RNA Sequencing in Systemic Lupus Erythematosus
  • 2023
  • RNA Sequencing
  • Animal
  • Case Study
Application of Whole Transcriptome Sequencing in Cancer Research
  • 2023
  • Whole Transcriptome Sequencing
  • Human
  • Case Study
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
  • 2023
  • Whole Genome Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • CELL
  • IF 66.85
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
  • 2023
  • De novo Sequencing, Whole Genome Sequencing, Hi-C
  • Plant
  • NATURE GENETICS
  • IF 41.307
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Human
  • Molecular Cancer
  • IF 41.444
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Animal
  • CELL
  • IF 66.85
An unusual tandem kinase fusion protein confers leaf rust resistance in wheat
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Plant
  • NATURE GENETICS
  • IF 41.307
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
  • 2023
  • Whole Genome Sequencing
  • Human
  • NATURE
  • IF 64.8
A graph-based genome and pan-genome variation of the model plant Setaria
  • 2023
  • Whole Genome Sequencing
  • Plant
  • NATURE GENETICS
  • IF 30.8
Historical DNA reveals climate adaptation in an endangered songbird
  • 2023
  • Whole Genome Sequencing
  • Animal
  • Nature Climate Change
  • IF 30.7
Rapid Discovery of Functional NLRs Using the Signature of High Expression, High-Throughput Transformation, and Large-Scale Phenotyping
  • 2023
  • Whole Genome Sequencing
  • Animal
  • CELL
  • IF 66.85
The evolution of white-tailed jackrabbit camouflage in response to past and future seasonal climates
  • 2023
  • Whole Genome Sequencing
  • Animal
  • SCIENCE
  • IF 63.714
Precise integration of large DNA sequences in plant genomes using PrimeRoot editors
  • 2023
  • Whole Genome Sequencing
  • Plant
  • NATURE BIOTECHNOLOGY
  • IF 68.164
Improved cytosine base editors generated from TadA variants
  • 2023
  • Whole Genome Sequencing
  • Human
  • NATURE BIOTECHNOLOGY
  • IF 46.9
Resurrection of endogenous retroviruses during aging reinforces senescence
  • 2023
  • RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Microbial
  • CELL
  • IF 66.85
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
  • 2023
  • RNA Sequencing, Whole Exome Sequencing
  • Human
  • NATURE
  • IF 64.8
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
  • 2023
  • Whole Exome Sequencing
  • Human
  • CANCER CELL
  • IF 50.3
Camrelizumab Plus Apatinib in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: An Open-Label, Single-Arm, Phase II Study
  • 2023
  • Whole Exome Sequencing
  • Human
  • JOURNAL OF CLINICAL ONCOLOGY
  • IF 50.717
Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities
  • 2023
  • Whole Exome Sequencing
  • Human
  • GUT
  • IF 31.793
RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification
  • 2023
  • Ribo-seq
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 39.3
Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders.
  • 2023
  • RNA Sequencing
  • Microbial
  • Cell Host & Microbe
  • IF 31.316
Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
  • 2023
  • Metatranscriptome Sequencing
  • Animal
  • Nature Microbiology
  • IF 30.964
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis
  • 2023
  • Metagenomics, RNA Sequencing
  • Human
  • NATURE IMMUNOLOGY
  • IF 30.5
Differential Responses of the Gut Microbiome and Resistome to Antibiotic Exposures in Infants and Adults
  • 2023
  • 16S/18S/ITS Amplicon Metagenomic Sequencing, Metagenomics
  • Microbial
  • Cell Host & Microbe
  • IF 31.316
Hyperactive nanobacteria with host-dependent traits pervade Omnitrophota
  • 2023
  • Metagenomics
  • Microbial
  • Nature Microbiology
  • IF 30.964
Linking chromatin acylation mark-defined proteome and genome in living cells
  • 2023
  • ATAC-seq, ChIP-seq, RNA Sequencing, Hi-C
  • Human
  • CELL
  • IF 66.85
Nano-DMS-MaP allows isoform-specific RNA structure determination
  • 2023
  • RNA Sequencing, Whole Genome Sequencing
  • Human
  • NATURE METHODS
  • IF 47.99
ThPOK is a critical multifaceted regulator of myeloid lineage development
  • 2023
  • RNA Sequencing
  • Human
  • NATURE IMMUNOLOGY
  • IF 30.5
cGLRs are a diverse family of pattern recognition receptors in innate immunity
  • 2023
  • RNA Sequencing
  • Human
  • CELL
  • IF 64.5
Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner
  • 2023
  • RNA Sequencing
  • Animal
  • Cell Discovery
  • IF 33.5
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results
  • 2023
  • RNA Sequencing
  • Human
  • NATURE MEDICINE
  • IF 87.241
Mitotic clustering of pulverized chromosomes from micronuclei
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
  • 2023
  • RNA Sequencing
  • Human
  • CELL RESEARCH
  • IF 46.297
The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
  • 2023
  • RNA Sequencing
  • Plant
  • NATURE GENETICS
  • IF 41.307
3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
  • 2023
  • RNA Sequencing
  • Human
  • Molecular Cancer
  • IF 41.444
Climate change and vector-borne diseases: a multi-omics approach of temperature-induced changes in the mosquito
  • 2023
  • RNA Sequencing
  • Animal
  • JOURNAL OF TRAVEL MEDICINE
  • IF 39.194
Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Microfluidic templated stem cell spheroids microneedles for diabetic wound treatment
  • 2023
  • RNA Sequencing
  • Human
  • ADVANCED MATERIALS
  • IF 32.086
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice
  • 2023
  • RNA Sequencing
  • Microbial
  • Cell Host & Microbe
  • IF 31.316
Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles
  • 2023
  • RNA Sequencing
  • Human
  • Cell Host & Microbe
  • IF 31.316
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
  • 2023
  • RNA Sequencing
  • Microbial
  • IMMUNITY
  • IF 43.474
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment.
  • 2023
  • RNA Sequencing
  • Human
  • CANCER CELL
  • IF 38.585
GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiation
  • 2023
  • RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
  • 2023
  • RNA Sequencing
  • Human
  • CELL
  • IF 66.85
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
  • 2023
  • RNA Sequencing
  • Human
  • CANCER CELL
  • IF 38.585
Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
  • 2023
  • RNA Sequencing
  • Human
  • Cancer Discovery
  • IF 38.272
Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Precise transcript targeting by CRISPR-Csm complexes
  • 2023
  • RNA Sequencing
  • Microbial
  • NATURE BIOTECHNOLOGY
  • IF 68.164
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies
  • 2023
  • RNA Sequencing
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 38.104
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
  • 2023
  • RNA Sequencing
  • Animal
  • Cell Metabolism
  • IF 31.373
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation
  • 2023
  • RNA Sequencing
  • Human
  • NATURE IMMUNOLOGY
  • IF 31.25
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
  • 2023
  • RNA Sequencing, CUT&Tag
  • Human
  • Signal Transduction and Targeted Therapy
  • IF 39.3
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing
  • 2023
  • CRISPR Screening (off-target)
  • Human
  • Molecular Cancer
  • IF 37.3
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation
  • 2023
  • CRISPR Screening (off-target)
  • Animal
  • CELL RESEARCH
  • IF 46.297
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs
  • 2023
  • ChIP-seq, RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • CELL
  • IF 64.5
Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells
  • 2023
  • ChIP-seq, RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • Cell Discovery
  • IF 38.079
Rewiring cancer drivers to activate apoptosis
  • 2023
  • ChIP-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 64.8
(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
  • 2023
  • ChIP-seq, RNA Sequencing
  • Human
  • Cancer Discovery
  • IF 38.272
Cycles of satellite and transposon evolution in Arabidopsis centromeres
  • 2023
  • ChIP-seq
  • Plant
  • NATURE
  • IF 69.504
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer
  • 2023
  • ATAC-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Cell Reprogramming-Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase-Separated Biomolecular Condensates
  • 2023
  • ATAC-seq
  • Human
  • ADVANCED MATERIALS
  • IF 32.086
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs
  • 2023
  • ATAC-seq
  • Microbial
  • NATURE IMMUNOLOGY
  • IF 31.25
Annelid functional genomics reveal the origins of bilaterian life cycles
  • 2023
  • ATAC-seq
  • Animal
  • NATURE
  • IF 69.504
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • SCIENCE
  • IF 63.714
Lysine catabolism reprograms tumour immunity through histone crotonylation
  • 2023
  • 10X Genomics single cell sequencing, ChIP-seq, RNA Sequencing
  • Human
  • NATURE
  • IF 69.504
Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • CELL
  • IF 66.85
A differentiation roadmap of murine placentation at single-cell resolution
  • 2023
  • 10X Genomics single cell sequencing
  • Animal
  • Cell Discovery
  • IF 38.079
NK-like CD8+ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • Science Immunology
  • IF 30.63
Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • Science Immunology
  • IF 30.63
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
  • 2023
  • 10X Genomics single cell sequencing
  • Microbial
  • NATURE MATERIALS
  • IF 47.656
Single-cell transcriptomic analysis of endometriosis
  • 2023
  • 10X Genomics single cell sequencing
  • Human
  • NATURE GENETICS
  • IF 41.307
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
  • 2023
  • 16S/18S/ITS Amplicon Metagenomic Sequencing, RNA Sequencing
  • Microbial
  • Case Study
Novogene Single-cell and Spatial Multi-omics Case Study
  • 2023
  • Single Cell RNA Sequencing
  • Human
  • Case Study
A survey of the sorghum transcriptome using single-molecule long reads
  • 2023
  • Isoform Sequencing
  • Plant
  • Case Study
Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis summary
  • 2023
  • Target Region Sequencing
  • Human
  • Case Study
Bat Immunity: Unlocking the Lineage-Specific Molecular Adaptations with Genetic Bases
  • 2023
  • De novo Sequencing, Whole Exome Sequencing, Hi-C
  • Animal
  • Case Study
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
  • 2023
  • Whole Genome Sequencing
  • Plant
  • Case Study
Synergetic effects of microbial-phytoremediation reshape microbial communities and improve degradation of petroleum contaminants
  • 2022
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • IF 10.58
Biosynthesis and recycling of magnetite nanocatalysts from Fe-rich sludge
  • 2022
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • IF 10.2
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis
  • 2022
  • Reduced Representation Bisulfite Sequencing (RRBS)
  • Animal
  • IF 14.87
Histone H3K27 Methylation Perturbs Transcriptional Robustness and Underpins Dispensability of Highly Conserved Genes in Fungi
  • 2022
  • Whole Genome Bisulfite Sequencing (WGBS)
  • Microbial
  • IF 16.24
Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus
  • 2022
  • Whole Transcriptome Sequencing
  • Animal
  • IF 18.187
Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis
  • 2022
  • Whole Transcriptome Sequencing
  • Animal
  • IF 15.828
Metagenomics combined with comprehensive validation as a public health risk assessment tool for urban and agricultural run-off
  • 2022
  • Metagenomics
  • Microbial
  • IF 11.236
Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
  • 2022
  • Whole Exome Sequencing, Whole Transcriptome Sequencing
  • Animal
  • IF 14.957
The dynamics of hybridisation between an avian island endemic and a recent coloniser
  • 2022
  • Whole Genome Sequencing
  • Animal
  • Case Study
Applications of Single-cell sequencing in stem cells, cancer, and skin research
  • 2022
  • Single Cell RNA Sequencing
  • Human
  • Case Study
The first fungi: mode of delivery determines early life fungal colonization in the intestine of preterm infants
  • 2022
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Human
  • Case Study
A Fifteen-Gene Classifier to Predict Neoadjuvant Chemotherapy Responses in Patients with Stage IB to IIB Squamous Cervical Cancer
  • 2021
  • Whole Exome Sequencing
  • Human
  • Advanced Science
  • IF15.84
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
  • 2021
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • IF 12.121
Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade
  • 2021
  • RNA Sequencing
  • Human
  • Cell Death & Differentiation
  • IF 10.717
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
  • 2021
  • ATAC-seq, ChIP-seq, Whole Genome Bisulfite Sequencing (WGBS)
  • Animal
  • Nucleic Acids Res
  • IF 11.501
High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming
  • 2021
  • Whole Genome Sequencing
  • Animal
  • Stem Cells Translational Medicine
  • IF 11.5
Large-scale translatome profiling annotates the functional genome and reveals the key role of genic 3′ untranslated regions in translatomic variation in plants
  • 2021
  • RNA Sequencing, Ribo-seq
  • Plant
  • Plant Communications
Homology-mediated inter-chromosomal interactions in hexaploid wheat lead to specific subgenome territories following polyploidization and introgression
  • 2021
  • RNA Sequencing, Whole Genome Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Plant
  • Genome Biology
  • IF 10.806
The Genetic Landscape of Hepatocellular Carcinoma: The Role of One Oncogene.
  • 2021
  • Whole Exome Sequencing
  • Human
  • Case Study
A modern Egyptian: the first comprehensive Egyptian reference genome
  • 2021
  • De novo Sequencing
  • Human
The Gut Microbiome and Energy Source of the Giant Panda
  • 2021
  • Metagenomics
  • Human
  • Case Study
SMRT sequencing yields the chromosome-scale reference genome of tea tree, Camellia sinensis var. sinensis
  • 2020
  • De novo Sequencing
  • Plant
  • BioRxiv
The genome of jojoba (Simmondsia chinensis): A taxonomically isolated species that directs wax ester accumulation in its seeds
  • 2020
  • De novo Sequencing
  • Plant
  • Science Advances
  • IF 12.804
SMRT sequencing generates the chromosome-scale reference genome of tropical fruit mango Mangifera indica
  • 2020
  • De novo Sequencing
  • Plant
  • BioRxiv
Horizontal gene transfer of Fhb7 for Fusarium head blight resistance in wheat
  • 2020
  • De novo Sequencing, RNA Sequencing
  • Plant
  • Science
  • Case Study
A Genomic and Epigenomic Atlas of Prostate Cancer in Asian Populations
  • 2020
  • RNA Sequencing, Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • Nature Genetics
Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat
  • 2020
  • Plant
  • Science
Resistance Gene Cloning from a Wild Crop Relative by Sequence Capture and Association Genetics
  • 2020
  • Target Region Sequencing
  • Plant
  • Nature Biotechnology
Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma
  • 2020
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Human
  • Genome Medicine
  • IF 10.675
Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy
  • 2020
  • Whole Genome Sequencing
  • Microbial
  • Advanced science
  • IF 15.84
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavio
  • 2019
  • 10X Genomics single cell sequencing
  • Animal
  • Cell
  • 31.398
B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
  • 2019
  • 10X Genomics single cell sequencing
  • Animal
  • Nature Communications
  • 11.878
Pathogen-targeting glycovesicles as a therapy for salmonellosis
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Communications
  • 11.878
Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Advanced Science
  • 15.804
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
  • 2019
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Cell Host & Microbe
  • 17.87
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.
  • 2019
  • ChIP-seq
  • Human
  • nature communications
  • 12.353
A circRNA signature predicts postoperative recurrence in stage II/III colon cancer
  • 2019
  • circular RNA Sequencing
  • Human
  • EMBO Mol Med
  • 10.624
The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesis
  • 2019
  • De novo Sequencing
  • Plant
  • Nature communications
  • 12.353
The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesis
  • 2019
  • De novo Sequencing
  • Plant
  • Nature communications
  • 12.353
Penaeid shrimp genome provides insights into benthic adaptation and frequent molting
  • 2019
  • De novo Sequencing
  • Animal
  • Nature communications
  • 12.353
Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior
  • 2019
  • Metabonomics
  • Animal
  • Cell
  • 36.216
Marine biofilms constitute a bank of hidden microbial diversity and functional potential
  • 2019
  • Metagenomics
  • Microbial
  • Nature Communications
  • 11.878
Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing
  • 2019
  • Metagenomics
  • Microbial
  • Microbiome
  • 10.465
Architecture of African Swine Fever Virus and implications for viral assembly
  • 2019
  • Proteomics
  • Microbial
  • Science
  • 41.037
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
  • 2019
  • Proteomics
  • Animal
  • Nature Communications
  • 12.353
RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening
  • 2019
  • meRIP-seq
  • Plant
  • Genome Biology
  • 14.028
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas
  • 2019
  • RNA Sequencing
  • Human
  • Acta Pharmaceutica Sinica B
  • 17.943
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
  • 2019
  • RNA Sequencing
  • Animal
  • Circulation Research
  • 15.862
Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT1 receptor in bovine mammary epithelial cells
  • 2019
  • RNA Sequencing
  • Animal
  • Journal of pineal research
  • 15.211
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
  • 2019
  • RNA Sequencing
  • Human
  • Nature Communications
  • 12.353
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction
  • 2019
  • RNA Sequencing
  • Animal
  • Nature Communications
  • 12.353
The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression
  • 2019
  • RNA Sequencing
  • Human
  • Science Advances
  • 11.804
Spliceosome disassembly factors ILP1 and NTR1 promote miRNA biogenesis in Arabidopsis thaliana
  • 2019
  • small RNA Sequencing
  • Plant
  • Nucleic Acids Research
  • 11.147
HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in Humans
  • 2019
  • Target Region Sequencing
  • Human
  • Hepatology
  • 14.079
Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome highlight T cell-initiated autoimmunity
  • 2019
  • Whole Exome Sequencing
  • Human
  • Annals of The Rheumatic Diseases
  • 14.299
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
  • 2019
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • 11.878
Phylogenomics Reveals an Ancient Hybrid Origin of the Persian Walnut
  • 2019
  • Whole Genome Sequencing
  • Plant
  • Molecular Biology and Evolution
  • 14.797
Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease
  • 2019
  • Whole Genome Sequencing
  • Animal
  • iScience
Clam genome sequence clarifies the molecular basis of its benthic adaptation and extraordinary shell color diversity
  • 2019
  • Whole Genome Sequencing
  • Animal
  • iScience
The chromosomal-level genome assembly and comprehensive transcriptomes of Chinese razor clam (Sinonovacula constricta) with deep-burrowing life style and broad-range salinity adaptation
  • 2019
  • Whole Genome Sequencing
  • Animal
  • BioRxiv
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
  • 2019
  • Whole Genome Sequencing
  • Human
  • nature
  • 41.577
Genomic Sequencing Identifies WNK2 as a Driver in hepatocellular carcinoma and a Risk Factor for Early Recurrence
  • 2019
  • Whole Genome Sequencing
  • Human
  • Journal of Hepatology
  • 18.946
The allotetraploid origin and asymmetrical genome evolution of common carp Cyprinus carpio
  • 2019
  • Whole Genome Sequencing
  • Animal
  • Acta Pharmaceutica Sinica B
  • 12.353
Comparative Population Genomics of Bread Wheat (Triticum aestivum) Reveals Its Cultivation and Breeding History in China.
  • 2019
  • Whole Genome Sequencing
  • Plant
  • BioRxiv
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
  • 2018
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Human
  • Nature Communications
  • 12.124
The Gastrodia elata genome provides insights into plant adaptation to heterotrophy
  • 2018
  • De novo Sequencing
  • Plant
  • Nature Communications
  • 12.353
A genome for gnetophytes and early evolution of seed plants
  • 2018
  • De novo Sequencing
  • Plant
  • Nature Plants
  • 10.3
Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response
  • 2018
  • Isoform Sequencing
  • Animal
  • Cell
  • 31.398
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.
  • 2018
  • meRIP-seq
  • Human
  • Hepatology
  • 13.246
The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts
  • 2018
  • RNA Sequencing
  • Human
  • Genome Biology
  • 11.908
Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis
  • 2018
  • RNA Sequencing
  • Animal
  • Nucleic Acids Research
  • 10.16
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor
  • 2018
  • Whole Exome Sequencing
  • Human
  • Cell
  • 31.398
Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension
  • 2018
  • Whole Exome Sequencing
  • Human
  • European Respiratory journal
  • 12.242
Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
  • 2018
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • 12.124
A mapping framework of competition–cooperation QTLs that drive community dynamics
  • 2018
  • Whole Genome Sequencing
  • Microbial
  • NATURE COMMUNICATIONS
  • 12.353
Resequencing core collection of upland cotton (Gossypium hirsutum) identifies genomic variation and loci influencing quality and yield of fiber
  • 2018
  • Whole Genome Sequencing
  • Plant
  • Nature Genetics
  • 27.959
Genetic variation in PTPN1 contributes to Metabolic Adaptation to High-Altitude Hypoxia in Tibetan Migratory Locusts
  • 2018
  • Whole Genome Sequencing
  • Animal
  • Nature Communications
  • 12.353
Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis
  • 2018
  • Whole Genome Sequencing
  • Plant
  • Nature Communications
  • 12.124
Continental-scale pollution of estuaries with antibiotic resistance genes
  • 2017
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Microbiology
  • 14.182
The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
  • 2017
  • 16S/18S/ITS Amplicon Metagenomic Sequencing
  • Microbial
  • Nature Communications
  • 11.329
A Natural Allele of a Transcription Factor in Rice Confers Broad-Spectrum Blast Resistance
  • 2017
  • ChIP-seq
  • Plant
  • Cell
  • 30.41
Scallop genome provides insights into evolution of bilaterian karyotype and development
  • 2017
  • De novo Sequencing
  • Animal
  • Nature Ecology & Evolution
The Apostasia genome and the evolution of orchids
  • 2017
  • De novo Sequencing
  • Plant
  • Nature
  • 40.137
Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins
  • 2017
  • De novo Sequencing
  • Animal
  • Nature Communications
  • 12.124
The Aegilops tauschiigenome reveals multipleimpacts of transposons
  • 2017
  • De novo Sequencing
  • Plant
  • Nature Plants
  • 10.3
Lineage-specific functions of TET1 in the postimplantation mouse embryo
  • 2017
  • Oxidative Bisulfite Sequencing (oxBS)
  • Animal
  • Nature Genetics
  • 27.959
Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction
  • 2017
  • Pan Genome
  • Plant
  • Nature Genetics
  • 27.959
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
  • 2017
  • Whole Exome Sequencing
  • Human
  • Nature Communications
  • 12.124
Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma
  • 2017
  • Whole Genome Sequencing
  • Human
  • Gastroenterology
  • 18.392
SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling
  • 2016
  • RNA Sequencing
  • Animal
  • Cell Stem Cell
  • 22.268
Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes
  • 2016
  • RNA Sequencing
  • Microbial
  • Genome Research
  • 14.63
Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells
  • 2016
  • Whole Exome Sequencing
  • Human
  • Cell Research
  • 15.606
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome
  • 2016
  • Whole Exome Sequencing
  • Human
  • American Journal of Human Genetics
  • 10.794
The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
  • 2016
  • Whole Genome Sequencing
  • Human
  • Nature
  • 38.138
DNA ethylation and chromatin accessibility profiling of mouse and human fetal germ cells
  • 2016
  • Whole Genome Sequencing
  • Human
  • Cell Research
  • 14.812
Comprehensive Variation Discovery and Recovery of Missing Sequence in the Pig Genome using Multiple De Novo Assemblies
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Genome Research
  • 14.381
Population genomics reveals low genetic diversity and adaptation to hypoxia in snub-nosed monkeys
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
History and temperate adaptation of the honey bee subspecies Apis mellifera sinisxinyuan n. ssp.
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Molecular Biology & Evolution
  • 13.649
Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies
  • 2016
  • Whole Genome Sequencing
  • Animal
  • Genome Research
  • 11.351
Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement
  • 2015
  • De novo Sequencing
  • Plant
  • Nature Biotechnology
  • 41.514
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
  • 2015
  • RNA Sequencing
  • Animal
  • Nature Communications
  • 11.47
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history
  • 2014
  • De novo Sequencing
  • Animal
  • Nature Genetics
  • 29.352
De novo assembly of soybean wild relatives for pan-genome analysis of diversity and agronomic traits
  • 2014
  • Pan Genome
  • Plant
  • Nature Biotechnology
  • 41.514
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas
  • 2014
  • RNA Sequencing
  • Human
  • Genome Research
  • 14.63
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
  • 2014
  • Whole Genome Bisulfite Sequencing (WGBS)
  • Human
  • Genome Biology
  • 10.81
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wile boars
  • 2013
  • De novo Sequencing
  • Animal
  • Nature Genetics
  • 29.65
Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau
  • 2013
  • De novo Sequencing
  • Animal
  • Nature Communications
  • 10.74
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
  • 2013
  • RNA Sequencing
  • Human
  • Nature Structural & Molecular Biology
  • 11.633
The genetic basis of whilte tigers
  • 2013
  • Whole Genome Sequencing
  • Animal
  • Current Biology
  • 10.445
Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing
  • 2012
  • Whole Genome Sequencing
  • Human
  • Science
  • 31.027
Whole-genome sequencing of Berkshire (European native pig) provides insights into its origin and domestication
  • 2012
  • Whole Genome Sequencing
  • Animal
  • Nature Communications
  • 10.015

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