RNA sequencing (RNA-seq) has emerged as a powerful tool for gene expression analysis, allowing for the comprehensive study of the transcriptome. It has become an essential technique in various research fields, including disease research. Here, we will explore how RNA-seq was applied to investigate the mechanism of synaptic stripping by microglia in a mouse model of lupus. This study, from Nanjing Drum Tower Hospital collaborated with Nanjing University of Chinese Medicine titled, “Neuronal NR4A1 deficiency drives coordinated synaptic stripping by microglia in a mouse model of lupus”, used RNA-seq and other research methods to clarify that synaptic loss is the early pathology of lupus brain injury, and microglia, complement signals and neurons participate in this process.
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