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Bat Immunity: Unlocking the Lineage-Specific Molecular Adaptations with Genetic Bases


In this study, researchers developed a novel genome assembly pipeline to produce a genome of Cynopterus sphinx. They employed comparative genomics methods, along with functional assays, to investigate immune-related adaptations among the Pteropodidae family, other bats, and mammals. The study aims to determine whether variations in viral load result from the unique adaptations within the Pteropodidae family and to provide insights into the unique genetic bases of bat immunity for future studies that link the evolution and ecology of specific bats and their zoonotic viruses.

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