At present, researchers have a general understanding of the role of DNMT1 in the methylation maintenance mechanism. However, there is still a lack of precise quantitative studies on DNMT1’s preference for methylation states (hemimethylated, unmethylated, and hemihydroxymethylated) and substrate context sequences. Through the combination of the Deep Enzymology Approach and Next-Generation Sequencing, a comprehensive DNMT1 preference profile was provided using bisulfite methylation sequencing technology.
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