Introduction:

Prostate cancer is a leading cause of cancer-related mortality in American men. Chemoprevention of prostate cancer remains appealing for decreasing the morbidity and mortality associated with this disease. Withaferin A (WA) is a promising phytochemical exhibiting in vitro and in vivo anticancer activities against prostate and other cancers, but the mechanism of its action is not fully understood. In this study, RNA-seq analysis were performed using 22Rv1 human prostate cancer cell line to identify mechanistic targets of WA.

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