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Novogene reveals the whole-genome of golden snub-nosed monkey

Novogene reveals the whole-genome of golden snub-nosed monkey

Researchers from Novogene and Chinese academy of science have cooperated to complete whole-genome sequencing of the golden snub-nosed monkey. This new work provides support to the further investigation on dietary adaptations and evolutionary history of colobines. Detailed results have been reported in Nature Genetics on November, 2nd, 2014.


Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history

Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146× coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30× coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.

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Figure-Phylogenetic tree and estimated divergence times for GSM and other mammals.