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Human Microbiome

The importance and function of the human gut microbiome has gained unprecedented traction in recent years and the contribution of Next-Generation Sequencing (NGS) technologies to this research area cannot be disputed. Shotgun and amplicon-based metagenomic sequencing can detect microbiome function and individual species within it, respectively. The composition of the microbiome contributes to overall health and protection from pathogenic strains and NGS has provided data to allow links to be drawn between various diseases and microbiome diversity and function. A lot of work remains to be done in confirming causality in this context, and NGS can be of assistance here.

Genomics Application in Human Microbiome

  • Metagenomic analysis of infant faecal matter can be used to identify strains related to mode of delivery and post-birth interventions for preterm infants.
  • Combining 16S rRNA metagenomic data with functional analysis can provide information on the biochemical processes being carried out by the microbiome that either contribute or are detrimental to human health.

Related NGS Solutions