The study of the human microbiome has gained unprecedented traction in recent years and has been advanced through the use of Next Generation Sequencing (NGS) technologies. For example, environmental factors, diet, and individual genetics all contribute to the diversity of the human skin and gut microbiome. The composition of the microbiome has been shown to impact an individual’s overall well-being and may even confer protection from pathogenic strains. Shotgun and amplicon-based metagenomic sequencing can provide insights to the functions and diversity of the human microbiome and reveal potential links between the microbiome and various health issues, such as obesity, metabolic diseases, and autistic symptoms in children (1). In addition, gut microbiome modulation has been shown to be a potential therapeutic option for ADHD (2). Active research in human health is underway and NGS tools remain a powerful tool to drive new discoveries.
- 1. Anshula Mehra, et al. Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives, Journal of Traditional and Complementary Medicine, (2022)
- 2. Hooi SL, et al. A case report of improvement on ADHD symptoms after fecal microbiota transplantation with gut microbiome profiling pre- and post-procedure. Curr Med Res Opin. (2022)
Genomics Application in Human Microbiome
- Metagenomic analysis of infant faecal matter can be used to identify strains related to mode of delivery and post-birth interventions for preterm infants.
- Combination of 16S rRNA metagenomic data with functional analysis may provide information on the microbiome’s biochemical processes that either contribute to or are detrimental to human health.