Epigenome Sequencing

Analysis of the epigenome provides insights into epigenetic modifications that regulate gene expression and influence numerous biological processes. Epigenetic modifications, such as histone modifications and DNA methylation at cytosines, play a significant role in gene regulation and have been implicated in animal and plant development as well as various diseases, including cancer. Thus, understanding these epigenetic mechanisms is crucial for studying gene regulation and elucidating disease pathways which in turn can drive advances in applications including agriculture research, drug discovery and therapeutic interventions.

Novogene provides a range of epigenomic sequencing services to suit your needs. Our services include – whole-genome methylation sequencing (whole genome bisulfite sequencing as well as enzymatic methyl sequencing) and reduced representation bisulfite sequencing (RRBS) for the precise analysis of methylated cytosines. Additionally, we can also offer methylation detection by long read sequencing platforms from PacBio and ONT. We provide chromatin immunoprecipitation sequencing (ChIP-seq) and RNA immunoprecipitation sequencing (RIP-seq) services that enable researchers to analyze protein-DNA and protein-RNA interactions, respectively, providing insight into binding motifs and the regulatory roles of nucleic acid binding proteins. Lastly, we also sequence premade libraries to support ATAC-seq projects (both bulk and single-cell).