{"id":38366,"date":"2026-03-23T00:16:59","date_gmt":"2026-03-23T07:16:59","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?post_type=resources&#038;p=38366"},"modified":"2026-03-23T00:54:37","modified_gmt":"2026-03-23T07:54:37","slug":"deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/us-en\/resources\/publications\/deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states\/","title":{"rendered":"Deep plasma proteome profiling reveals biomarker signatures for early detection of type 2 diabetes and prediabetes states"},"content":{"rendered":"<div class=\"zuobian\">\n<h5>Introduction:<\/h5>\n<p style=\"margin-top:0;\">To better understand the molecular transition from prediabetes to Type 2 diabetes (T2D), researchers analyzed plasma from 508 individuals in the localized Bia\u0142ystok PLUS cohort. Utilizing Olink Reveal\u2014a high-throughput proximity extension assay (PEA) technology measuring ~1,000 circulating proteins\u2014the study mapped temporal metabolic signatures during oral glucose tolerance tests.<br \/>\nThis deep proteomic profiling successfully identified distinct early biomarkers for impaired glucose metabolism, such as BAIAP2 for general hyperglycemia and RTN4R for prediabetic states. By moving beyond standard clinical metrics, these insights lay a strong foundation for personalized medicine and precision diagnostics in metabolic syndrome.\n<\/p>\n<p style=\"display: inline-block;padding: 10px 20px;background-color: #44944a;border-radius: 20px;margin: 0;\"><a class=\"brochure-dllink\" style=\"color: #fff;font-size: 20px;    font-family: 'Merriweather-Bold', Arial;\" view-href=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2025\/10\/Case-Study_2026_Olink-Reveal.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download Now<\/a><\/p>\n<\/div>\n<div class=\"youbian\">\n<p><img decoding=\"async\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2026\/03\/2026032301.jpg\" alt=\"\" style=\"border: 2px solid #ccc;\"\/><\/p>\n<\/div>\n<style>.zuobian {width: 57%;float: left;margin-bottom: 30px;}.youbian {width: 35%;float: left;margin-left: 30px;margin-top:0;}\n@media all and (min-width: 350px) and (max-width: 760px) {.zuobian {width: 100%;}.youbian {width: 80%;}}<\/style>\n","protected":false},"featured_media":38368,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Deep plasma proteome profiling reveals biomarker signatures for early detection of type 2 diabetes and prediabetes states - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deep plasma proteome profiling reveals biomarker signatures for early detection of type 2 diabetes and prediabetes states\" \/>\n<meta property=\"og:description\" content=\"Introduction: To better understand the molecular transition from prediabetes to Type 2 diabetes (T2D), researchers analyzed plasma from 508 individuals in the localized Bia\u0142ystok PLUS cohort. Utilizing Olink Reveal\u2014a high-throughput proximity extension assay (PEA) technology measuring ~1,000 circulating proteins\u2014the study mapped temporal metabolic signatures during oral glucose tolerance tests. This deep proteomic profiling successfully identified\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-23T07:54:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2026\/03\/2026032302.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"752\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/deep-plasma-proteome-profiling-reveals-biomarker-signatures-for-early-detection-of-type-2-diabetes-and-prediabetes-states\/\",\"name\":\"Deep plasma proteome profiling reveals biomarker signatures for early detection of type 2 diabetes and prediabetes states - 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