{"id":38158,"date":"2025-10-31T02:48:19","date_gmt":"2025-10-31T09:48:19","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?post_type=resources&#038;p=38158"},"modified":"2025-10-31T02:48:19","modified_gmt":"2025-10-31T09:48:19","slug":"genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/","title":{"rendered":"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons"},"content":{"rendered":"<div style=\"display: flex;margin-top: 40px;flex-wrap: wrap; \">\n<div class=\"web-left\">\n<strong>Introduction:<\/strong><\/p>\n<p>We generated single-nucleus multiomic data from rhesus macaque dorsolateral prefrontal cortex (dlPFC) across fetal stages and performed integrated analyses to study neuronal maturation. Patch-seq was applied to acute dlPFC slices from 16 macaques, linking electrophysiological properties with gene expression profiles. Functional studies of RAPGEF4 and CHD8 revealed that their loss impairs morphological and electrophysiological maturation in macaque and human cortical neurons.\n<\/p>\n<p><\/p>\n<ul>\n<li style=\"margin-bottom: 10px;font-family: 'Montserrat-Regular', Arial;\">Identification of genes and regulatory networks driving primate neuronal maturation<\/li>\n<li style=\"margin-bottom: 10px;font-family: 'Montserrat-Regular', Arial;\">Discrete electrophysiological properties have distinct maturational profiles<\/li>\n<li style=\"margin-bottom: 10px;font-family: 'Montserrat-Regular', Arial;\">RAPGEF4 promotes the maturation of resting membrane potential and sodium current<\/li>\n<\/ul><\/div>\n<div class=\"web-right\" style=\"\" >\n<div style=\"padding:0 20px;\">\n<div>\n<a class=\"video-\" style=\"display: block;\" text=\"https:\/\/www.youtube.com\/embed\/MUWaZl8P8PY?si=jlqL_mOtzYJFFWm-\"><img decoding=\"async\" style=\"width: 100%;margin-top: 20px;\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2025\/10\/2025.10.8-Website-images_Oct-8-webinar-banner-watch-now.jpg\"><\/a>\n         <\/div>\n<p style=\"margin-bottom: 10px;\"><strong>Speakers:<\/strong><\/p>\n<p class=\"video-\" style=\"margin-bottom: 0;margin-top:0\"> Yu Gao<br \/> \u2014 Neuroscience Scientist<br \/>University of Wisconsin-Madison<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<style>.web-left {width: 35%;margin-right: 20px;}.web-right {width:60%;background-color: #f0f0f0;}@media screen and (min-width: 375px) and (max-width: 550px){.web-left {width: 100%;}.web-right {width: 100%;}}<\/style>\n","protected":false},"featured_media":38159,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons\" \/>\n<meta property=\"og:description\" content=\"Introduction: We generated single-nucleus multiomic data from rhesus macaque dorsolateral prefrontal cortex (dlPFC) across fetal stages and performed integrated analyses to study neuronal maturation. Patch-seq was applied to acute dlPFC slices from 16 macaques, linking electrophysiological properties with gene expression profiles. Functional studies of RAPGEF4 and CHD8 revealed that their loss impairs morphological and electrophysiological\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2025\/10\/2025.10.8-Website-images_Oct-8-webinar-banner-watch-now.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"998\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/\",\"name\":\"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons - Novogene\",\"isPartOf\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#website\"},\"datePublished\":\"2025-10-31T09:48:19+00:00\",\"dateModified\":\"2025-10-31T09:48:19+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.novogene.com\/us-en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resources\",\"item\":\"https:\/\/www.novogene.com\/us-en\/resources\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#website\",\"url\":\"https:\/\/www.novogene.com\/us-en\/\",\"name\":\"Novogene\",\"description\":\"USA Based Lab Guaranteed Data Security\",\"publisher\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.novogene.com\/us-en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#organization\",\"name\":\"Novogene\",\"url\":\"https:\/\/www.novogene.com\/us-en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/05\/20200506113246.png\",\"contentUrl\":\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/05\/20200506113246.png\",\"width\":941,\"height\":269,\"caption\":\"Novogene\"},\"image\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/NovogeneAmerica\/\",\"https:\/\/twitter.com\/Novogene_Global\",\"https:\/\/www.linkedin.com\/company\/novogene\/\",\"https:\/\/www.youtube.com\/c\/NovogeneGlobal\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons - Novogene","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.novogene.com\/us-en\/resources\/event\/genes-driving-electrophysiological-maturation-of-primate-prefrontal-neurons\/","og_locale":"en_US","og_type":"article","og_title":"Genes Driving Electrophysiological Maturation of Primate Prefrontal Neurons","og_description":"Introduction: We generated single-nucleus multiomic data from rhesus macaque dorsolateral prefrontal cortex (dlPFC) across fetal stages and performed integrated analyses to study neuronal maturation. 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