{"id":37178,"date":"2024-07-12T03:15:39","date_gmt":"2024-07-12T10:15:39","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?post_type=resources&#038;p=37178"},"modified":"2025-05-29T04:06:02","modified_gmt":"2025-05-29T11:06:02","slug":"therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/us-en\/resources\/publications\/therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells\/","title":{"rendered":"Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells"},"content":{"rendered":"<div class=\"zuobian\">\n<h5>Introduction:<\/h5>\n<p style=\"margin-top:0;\">Published on August 23, 2023, in the prestigious journal Nature, a study led by Dr Kazuo Isozaki, alongside teams from renowned oncology research centers, explored the intriguing evolution of resistance mutations in non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs). The research in this paper focused on the following key questions:<\/p>\n<ul>\n<li>How do non-small cell lung cancers (NSCLCs) develop resistance to tyrosine kinase inhibitors (TKIs)?<\/li>\n<li>What role does APOBEC3A-induced mutagenesis play in the evolution of drug-resistant cancer cells?<\/li>\n<li>Are there specific mutational signatures associated with APOBEC activity in TKI-treated tumors?<\/li>\n<li>Can inhibiting APOBEC3A expression or activity prevent or delay the emergence of drug resistance in NSCLC?<\/li>\n<\/ul>\n<p style=\"display: inline-block;padding: 10px 20px;background-color: #44944a;border-radius: 20px;margin: 0;\"><a class=\"brochure-dllink\" style=\"color: #fff;font-size: 20px;    font-family: 'Merriweather-Bold', Arial;\" view-href=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2024\/07\/Therapy-induced-APOBEC3A-Drives-Evolution-of-Persistent-Cancer-Cells-us.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download Now<\/a><\/p>\n<\/div>\n<div class=\"youbian\">\n<p><img decoding=\"async\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2024\/07\/introduction\u9875\u5c01\u9762-scaled.webp\" alt=\"\" \/><\/p>\n<\/div>\n<style>.zuobian {width: 57%;float: left;margin-bottom: 30px;}.youbian {width: 35%;float: left;margin-left: 30px;margin-top:0;}\n@media all and (min-width: 350px) and (max-width: 760px) {.zuobian {width: 100%;}.youbian {width: 80%;}}<\/style>\n","protected":false},"featured_media":37176,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells\" \/>\n<meta property=\"og:description\" content=\"Introduction: Published on August 23, 2023, in the prestigious journal Nature, a study led by Dr Kazuo Isozaki, alongside teams from renowned oncology research centers, explored the intriguing evolution of resistance mutations in non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs). The research in this paper focused on the following key questions:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-29T11:06:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2024\/07\/\u7f51\u9875\u9884\u89c8\u56fe.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"317\" \/>\n\t<meta property=\"og:image:height\" content=\"262\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/therapy-induced-apobec3a-drives-evolution-of-persistent-cancer_cells\/\",\"name\":\"Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells - 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