{"id":36813,"date":"2023-10-30T22:07:06","date_gmt":"2023-10-31T05:07:06","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?post_type=resources&#038;p=36813"},"modified":"2025-06-09T03:46:29","modified_gmt":"2025-06-09T10:46:29","slug":"drosophila-histone-demethylase-kdm5-regulates-social-behavior-through-immune-control-and-gut-microbiota-maintenance-2","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/us-en\/resources\/publications\/drosophila-histone-demethylase-kdm5-regulates-social-behavior-through-immune-control-and-gut-microbiota-maintenance-2\/","title":{"rendered":"Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance"},"content":{"rendered":"<div class=\"zuobian\">\n<h5>Introduction:<\/h5>\n<p style=\"margin-top:0;\">The gut microbiota can affect the symptoms of intellectual disability (ID) and autism spectrum disorder (ASD) diseases. Loss of function mutations in histone demethylases KDM5A, KDM5B, or KDM5C are found in patients with ID and ASD. However, the molecular mechanisms that regulate host-commensal microbiota homeostasis in normal and disease states remain largely unknown. Drosophila is a widely accepted model for studying behavior.<\/p>\n<p style=\"display: inline-block;padding: 10px 20px;background-color: #44944a;border-radius: 20px;margin: 0;\"><a class=\"brochure-dllink\" style=\"color: #fff;font-size: 20px;    font-family: 'Merriweather-Bold', Arial;\" view-href=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2023\/10\/Gut-Microbe-Case-study-Transcriptomics-16S-Immune-deficiency-IMD-Signaling-Pathway.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download Now<\/a><\/p>\n<\/div>\n<div class=\"youbian\">\n<p><img decoding=\"async\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2023\/10\/\u4f01\u4e1a\u5fae\u4fe1\u622a\u56fe_e55fdffe-9312-4d27-9250-d1cf8fa2a340.png\" alt=\"\" \/><\/p>\n<\/div>\n<style>.zuobian {width: 57%;float: left;margin-bottom: 30px;}.youbian {width: 35%;float: left;margin-left: 30px;margin-top:0;}\n@media all and (min-width: 350px) and (max-width: 760px) {.zuobian {width: 100%;}.youbian {width: 80%;}}<\/style>\n","protected":false},"featured_media":36815,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/resources\/publications\/drosophila-histone-demethylase-kdm5-regulates-social-behavior-through-immune-control-and-gut-microbiota-maintenance-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance\" \/>\n<meta property=\"og:description\" content=\"Introduction: The gut microbiota can affect the symptoms of intellectual disability (ID) and autism spectrum disorder (ASD) diseases. Loss of function mutations in histone demethylases KDM5A, KDM5B, or KDM5C are found in patients with ID and ASD. However, the molecular mechanisms that regulate host-commensal microbiota homeostasis in normal and disease states remain largely unknown. 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