{"id":33127,"date":"2022-04-20T23:49:35","date_gmt":"2022-04-21T06:49:35","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?post_type=resources&#038;p=33127"},"modified":"2025-05-29T03:38:58","modified_gmt":"2025-05-29T10:38:58","slug":"fine-particulate-matter-and-childhood-asthma","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/","title":{"rendered":"Fine particulate matter and childhood asthma"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/E7MWaKnH_zM\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Speaker Introduction:<br \/>\nRui Zheng, Ph.D., lecturer at Nanjing Medical University.<br \/>\nDr Zheng went to the National Institute of Environmental Health Sciences (NIEHS, USA) as a visiting Scholar. Her research focuses on environmental factors, epigenetics, exosomes, and disease susceptibility.<\/p>\n<p>Topic Introduction:<br \/>\nFine particulate matter induces childhood asthma attacks via extracellular vesicle-packaged let-7i-5p-mediated modulation of the MAPK signaling pathway<\/p>\n<p>Description:<br \/>\nFine particulate matter less than 2.5 \u03bcm in diameter (PM2.5) is a major risk factor for acute asthma attacks in children. However, the biological mechanism underlying this association remains unclear. In the present study, PM2.5-treated HBE cells-secreted extra-cellular vesicles (PM2.5-EVs) caused cytotoxicity in\u201chorizontal\u201d HBE cells and increased the contractility of\u201clongitudinal\u201d sensitive human bronchial smooth muscle cells (HBSMCs). RNA sequencing showed that let-7i-5p was significantly overexpressed inPM2.5-EVs and asthmatic plasma; additionally, its level was correlated with PM2.5 exposure in children with asthma. The combination of EV-packaged let-7i-5p and the traditional clinical biomarker IgE exhibited the best diagnostic performance (area under the curve (AUC) = 0.855, 95% CI = 0.786-0.923). Mechanistically,let-7i-5p was packaged into PM2.5-EVs by interacting with ELAVL1and internalized by both\u201chorizontal\u201d recipient HBE cells and\u201clongitudinal\u201drecipient-sensitive HBSMCs, with subsequent activation of the MAPK signaling pathway via suppression of its targetDUSP1. Furthermore, an injection of EV-packaged let-7i-5p intoPM2.5-treated juvenile mice aggravated asthma symptoms. This comprehensive study deciphered the remodeling of the extracellular environment mediated by the secretion of let-7i-5p-enriched EVs during PM2.5-induced asthma attacks and identified plasma-packaged let-7i-5p as a novel predictor of childhood asthma.<\/p>\n","protected":false},"featured_media":0,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fine particulate matter and childhood asthma - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fine particulate matter and childhood asthma\" \/>\n<meta property=\"og:description\" content=\"Speaker Introduction: Rui Zheng, Ph.D., lecturer at Nanjing Medical University. Dr Zheng went to the National Institute of Environmental Health Sciences (NIEHS, USA) as a visiting Scholar. Her research focuses on environmental factors, epigenetics, exosomes, and disease susceptibility. Topic Introduction: Fine particulate matter induces childhood asthma attacks via extracellular vesicle-packaged let-7i-5p-mediated modulation of the MAPK\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-29T10:38:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/\",\"name\":\"Fine particulate matter and childhood asthma - Novogene\",\"isPartOf\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#website\"},\"datePublished\":\"2022-04-21T06:49:35+00:00\",\"dateModified\":\"2025-05-29T10:38:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.novogene.com\/us-en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resources\",\"item\":\"https:\/\/www.novogene.com\/us-en\/resources\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Fine particulate matter and childhood asthma\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#website\",\"url\":\"https:\/\/www.novogene.com\/us-en\/\",\"name\":\"Novogene\",\"description\":\"USA Based Lab Guaranteed Data Security\",\"publisher\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.novogene.com\/us-en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#organization\",\"name\":\"Novogene\",\"url\":\"https:\/\/www.novogene.com\/us-en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/05\/20200506113246.png\",\"contentUrl\":\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/05\/20200506113246.png\",\"width\":941,\"height\":269,\"caption\":\"Novogene\"},\"image\":{\"@id\":\"https:\/\/www.novogene.com\/us-en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/NovogeneAmerica\/\",\"https:\/\/twitter.com\/Novogene_Global\",\"https:\/\/www.linkedin.com\/company\/novogene\/\",\"https:\/\/www.youtube.com\/c\/NovogeneGlobal\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Fine particulate matter and childhood asthma - Novogene","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.novogene.com\/us-en\/resources\/event\/fine-particulate-matter-and-childhood-asthma\/","og_locale":"en_US","og_type":"article","og_title":"Fine particulate matter and childhood asthma","og_description":"Speaker Introduction: Rui Zheng, Ph.D., lecturer at Nanjing Medical University. 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