{"id":38473,"date":"2026-06-07T08:02:51","date_gmt":"2026-06-07T15:02:51","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?page_id=38473"},"modified":"2026-06-07T08:10:27","modified_gmt":"2026-06-07T15:10:27","slug":"direct-methylation-sequencing-dmseq","status":"publish","type":"page","link":"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/direct-methylation-sequencing-dmseq\/","title":{"rendered":"Direct Methylation Sequencing (DM\u001eSeq)"},"content":{"rendered":"<div class=\"clear_p\" style=\"float: right;margin: 0 0 20px 50px\"><img decoding=\"async\" class=\"clear_img\" style=\"width: 286px;min-height:180px\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/07\/istockphoto-513110674-540x360-2.jpg\" alt=\"\"><\/p>\n<div class=\"col-sm-12 m-auto text-center\" style=\"padding-top: 20px;padding-left: 0\"><span style=\"float: left;background: #3f6992;height: 2.6875rem;width: 2.875rem\"><img decoding=\"async\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2021\/01\/Novogene-button-icon-20210129.png\" style=\"margin-top: 0.25rem\"><\/span><\/p>\n<div id=\"top_btn\" class=\"blue btn\" style=\"margin-top: 0px;padding: 8px 1.1875rem;float: left;background: #3789C7;border: none;line-height: 1.6875rem\">\n<a href=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2024\/02\/22-Detailed-Materials-for-WGBS-20240129.pdf\" class=\"\">Service Specifications<\/a><\/div>\n<\/div>\n<\/div>\n<p class=\"blue-box\" style=\"width:70%;background-color: #e2f2ff!important;padding: 20px;font-family: 'Montserrat-Regular', Arial;color: #032e53;font-size: 16px\">DNA methylation at cytosine (5mC) is a key epigenetic modification that regulates gene expression, chromatin structure, and genome stability. Dysregulated methylation drives tumorigenesis, neurodegenerative diseases, and complex disorders. Direct Methylation Sequencing (DM\u001eSeq) is a <strong>bisulfite\u001efree, enzymatic methyl\u001esequencing technology<\/strong> that detects 5mC at single\u001ebase resolution. It preserves DNA integrity, avoids harsh chemical damage, and enables accurate profiling even with low\u001einput or degraded samples.<\/p>\n<p style=\"line-height: 24px\">Novogene offers flexible DM\u001eSeq solutions tailored to your research needs:<\/p>\n<ul class=\"novo-ul\">\n<li><span style=\"font-family:'Merriweather-Bold' ,Airal\">Illumina 5\u001ebase chemistry:<\/span> Targets <span style=\"font-family:'Merriweather-Bold' ,Airal\">5mC only<\/span>, delivering clean, precise methylation calls ideal for standard epigenetics and SNV\u001eco\u001edetection studies.<\/li>\n<li><span style=\"font-family:'Merriweather-Bold' ,Airal\">Watchmaker TAPS+ chemistry:<\/span> Captures <span style=\"font-family:'Merriweather-Bold' ,Airal\">both 5mC and 5hmC<\/span>, providing a comprehensive view of active epigenetic landscapes for neuroscience, development, and cancer research.<\/li>\n<\/ul>\n<style>\n.novo-ul li{margin-bottom: 10px;}\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Service Specifications DNA methylation at cytosine (5mC) is a key epigenetic modification that regulates gene expression, chromatin structure, and genome stability. Dysregulated methylation drives tumorigenesis, neurodegenerative diseases, and complex disorders. Direct Methylation Sequencing (DM\u001eSeq) is a bisulfite\u001efree, enzymatic methyl\u001esequencing technology that detects 5mC at single\u001ebase resolution. It preserves DNA integrity, avoids harsh chemical damage, and<\/p>\n","protected":false},"author":14,"featured_media":0,"parent":2155,"menu_order":21,"comment_status":"closed","ping_status":"closed","template":"templates\/page-technical3.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Direct Methylation Sequencing (DM\u001eSeq) - Novogene<\/title>\n<meta name=\"description\" content=\"Novogene provides whole genome bisulfite sequencing (WGBS) to efficiently identify methylated cytosines on a genome-wide scale with a single nucleotide resolution.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/direct-methylation-sequencing-dmseq\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Direct Methylation Sequencing (DM\u001eSeq)\" \/>\n<meta property=\"og:description\" content=\"Novogene provides whole genome bisulfite sequencing (WGBS) to efficiently identify methylated cytosines on a genome-wide scale with a single nucleotide resolution.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/direct-methylation-sequencing-dmseq\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-07T15:10:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/07\/istockphoto-513110674-540x360-2.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/direct-methylation-sequencing-dmseq\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/direct-methylation-sequencing-dmseq\/\",\"name\":\"Direct Methylation Sequencing (DM\\u001eSeq) - 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