{"id":36640,"date":"2023-10-20T01:35:07","date_gmt":"2023-10-20T08:35:07","guid":{"rendered":"https:\/\/www.novogene.com\/us-en\/?page_id=36640"},"modified":"2025-04-23T02:32:37","modified_gmt":"2025-04-23T09:32:37","slug":"atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing","status":"publish","type":"page","link":"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing\/","title":{"rendered":"ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing)"},"content":{"rendered":"<div class=\"clear_p\" style=\"float: right; margin: 0 0 20px 50px;\">\n<img decoding=\"async\" class=\"clear_img\" style=\"width: 286px; min-height: 180px;\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/04\/istockphoto-493477826-540x360-2.jpg\" alt=\"\" \/><\/p>\n<div class=\"col-sm-12 m-auto text-center\" style=\"padding-top: 20px; padding-left: 0;\">\n<span style=\"float: left; background: #3f6992; height: 2.6875rem; width: 2.875rem;\"><img decoding=\"async\" style=\"margin-top: 0.25rem;\" src=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2021\/01\/Novogene-button-icon-20210129.png\" \/><\/span><\/p>\n<div id=\"top_btn\" class=\"blue btn\" style=\"margin-top: 0px; padding: 8px 1.1875rem; float: left; background: #3789C7; border: none; line-height: 1.6875rem;\"><a class=\"\" href=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2023\/12\/Assay-for-Transposase-Accessible-Chromatin-with-High-Throughput-Sequencing-ATAC-seq-20231219.pdf\">Service Specifications<\/a><\/div>\n<\/div>\n<\/div>\n<p class=\"blue-box\" style=\"width: 70%; background-color: #e2f2ff!important; padding: 20px; font-family: 'Montserrat-Regular', Arial; color: #032e53; font-size: 16px;\"><strong>ATAC-seq<\/strong> is a high-throughput sequencing method used to analyze <strong>genome-wide chromatin accessibility<\/strong>, which is crucial for understanding the global epigenetic regulation of gene expression. Chromatin accessibility refers to the extent to which nuclear macromolecules can interact with chromatinized DNA, enabling transcription and other biological processes. Consequently, ATAC-seq provides valuable insights into the genome&#8217;s regulatory landscape by identifying regions where DNA is accessible for binding by various cellular factors.<\/p>\n<p class=\"novo-p\">Leveraging <strong>Next Generation Sequencing (NGS)<\/strong> technology with the <strong>Illumina NovaSeq platform<\/strong>, Novogene\u2019s ATAC-seq service enables researchers to investigate genome-wide chromatin accessibility, a key factor in gene expression regulation. During ATAC-seq library preparation, sequencing adapters are inserted into <strong>open chromatin regions<\/strong> using the hyperactive <strong>Tn5 transposase<\/strong>. This allows for the capture of all open chromatin regions under specific space-time conditions, without being restricted to the binding sites of transcription factors or specific histone-modified regions like ChIP-seq.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Service Specifications ATAC-seq is a high-throughput sequencing method used to analyze genome-wide chromatin accessibility, which is crucial for understanding the global epigenetic regulation of gene expression. Chromatin accessibility refers to the extent to which nuclear macromolecules can interact with chromatinized DNA, enabling transcription and other biological processes. Consequently, ATAC-seq provides valuable insights into the genome&#8217;s<\/p>\n","protected":false},"author":14,"featured_media":0,"parent":2155,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"templates\/page-technical3.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) - Novogene<\/title>\n<meta name=\"description\" content=\"RRBS is a methodical and high-throughput approach for investigating the methylation profiles of the entire genome on a single resolution level.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing)\" \/>\n<meta property=\"og:description\" content=\"RRBS is a methodical and high-throughput approach for investigating the methylation profiles of the entire genome on a single resolution level.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/NovogeneAmerica\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-23T09:32:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/us-en\/wp-content\/uploads\/sites\/4\/2020\/04\/istockphoto-493477826-540x360-2.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Novogene_Global\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing\/\",\"url\":\"https:\/\/www.novogene.com\/us-en\/services\/research-services\/epigenome-sequencing\/atac-seq-assay-for-transposase-accessible-chromatin-with-sequencing\/\",\"name\":\"ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) - 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