{"id":34865,"date":"2022-11-13T19:31:57","date_gmt":"2022-11-14T03:31:57","guid":{"rendered":"https:\/\/www.novogene.com\/eu-en\/?post_type=resources&#038;p=34865"},"modified":"2024-06-04T03:17:48","modified_gmt":"2024-06-04T10:17:48","slug":"unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells","status":"publish","type":"resources","link":"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/","title":{"rendered":"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells"},"content":{"rendered":"<div class=\"zuobian\">\n<h5>Introduction:<\/h5>\n<p style=\"margin-top:0;\">Hormone dependent breast cancers (HDBCs) are routinely treated with adjuvant endocrine therapies (ETs) such as tamoxifen or aromatase inhibitors (AI) to abrogate oestrogen signalling. This treatment induces dormancy in cancer cells, a state characterised by cell cycle arrest and inhibition of replicative processes. These cells can reawaken from dormancy to facilitate relapse and metastasis. It has been previously shown that in 60% of relapse cases, there is no underlying genetic mutation in known cancer drivers that could explain drug resistance (Razavi et al., 2018). Even with this extensive research, whether these mutations exist before dormancy or are acquired de novo before awakening remains unclear. Due to the downregulation of DNA replication in dormant cells, which is required for Darwinian evolution and the acquirement of mutations, the hypothesis of this study is that there are non-genetic factors responsible for the reawakening of dormant cells.<\/p>\n<p style=\"display: inline-block;padding: 10px 20px;background-color: #44944a;border-radius: 20px;margin: 0;\"><a class=\"brochure-dllink\" style=\"color: #fff;font-size: 20px;    font-family: 'Merriweather-Bold', Arial;\" view-href=\"https:\/\/www.novogene.com\/eu-en\/wp-content\/uploads\/sites\/7\/2023\/10\/Unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download Now<\/a><\/p>\n<\/div>\n<div class=\"youbian\">\n<p><img decoding=\"async\" style=\"border:1px solid #000;\" src=\"https:\/\/www.novogene.com\/eu-en\/wp-content\/uploads\/sites\/7\/2022\/11\/HDBC-dormancy-case-study_1-724x1024-1.png\" alt=\"\" \/><\/p>\n<\/div>\n<style>.zuobian {width: 57%;float: left;margin-bottom: 30px;}.youbian {width: 35%;float: left;margin-left: 30px;margin-top:0;}\n@media all and (min-width: 350px) and (max-width: 760px) {.zuobian {width: 100%;}.youbian {width: 80%;}}<\/style>\n","protected":false},"featured_media":34863,"parent":0,"template":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.8 (Yoast SEO v20.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells - Novogene<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells\" \/>\n<meta property=\"og:description\" content=\"Introduction: Hormone dependent breast cancers (HDBCs) are routinely treated with adjuvant endocrine therapies (ETs) such as tamoxifen or aromatase inhibitors (AI) to abrogate oestrogen signalling. This treatment induces dormancy in cancer cells, a state characterised by cell cycle arrest and inhibition of replicative processes. These cells can reawaken from dormancy to facilitate relapse and metastasis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Novogene\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-04T10:17:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.novogene.com\/eu-en\/wp-content\/uploads\/sites\/7\/2022\/11\/HDBC-dormancy-case-study_1-724x1024-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"724\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/\",\"url\":\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/\",\"name\":\"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells - Novogene\",\"isPartOf\":{\"@id\":\"https:\/\/www.novogene.com\/eu-en\/#website\"},\"datePublished\":\"2022-11-14T03:31:57+00:00\",\"dateModified\":\"2024-06-04T10:17:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.novogene.com\/eu-en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resources\",\"item\":\"https:\/\/www.novogene.com\/eu-en\/resources\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.novogene.com\/eu-en\/#website\",\"url\":\"https:\/\/www.novogene.com\/eu-en\/\",\"name\":\"Novogene\",\"description\":\"Advancing\u00a0Genomics,\u00a0Improving\u00a0Life\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.novogene.com\/eu-en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells - Novogene","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.novogene.com\/eu-en\/resources\/publications\/unperturbed-dormancy-recording-reveals-stochastic-awakening-strategies-in-endocrine-treated-breast-cancer-cells\/","og_locale":"en_US","og_type":"article","og_title":"Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells","og_description":"Introduction: Hormone dependent breast cancers (HDBCs) are routinely treated with adjuvant endocrine therapies (ETs) such as tamoxifen or aromatase inhibitors (AI) to abrogate oestrogen signalling. 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